3-Fluorophenmetrazine (also known as 3F-Phenmetrazine, PAL-593, and 3-FPM) is a novel stimulant substance of the phenylmorpholine class. 3-FPM is a derivative of phenmetrazine, a once-popular stimulant substance that was clinically used as an anorectic in Europe in the 1950s.
It produces its activity by increasing the levels of serotonin, dopamine, and norepinephrine in the brain.
The synthesis and pharmacology of 3-FPM was first reported in a patent filed in 2011. Reports of human use first surfaced in early 2015 after it appeared for sale on the online research chemical market.
Subjective effects include stimulation, enhanced focus and motivation, thought acceleration, and euphoria. Users commonly report that 3-FPM produces classical stimulant effects comparable to those of amphetamine.
Many reports describe 3-FPM as having a relatively subtle and controlled stimulant effect which produces less nervousness, insomnia and euphoria than other stimulants, which makes it suitable as a study-aid or productivity-enhancer.
A few but significant number of anecdotal reports indicate some people experience serious nervous system reactions to 3-FPM.
Very little data exists about the pharmacological properties, metabolism, and toxicity of 3-FPM. Due to the lack of information on its properties, it is highly advised to use harm reduction practices if using this substance.
Buy 3-fpm ( 3-Fluorophenmetrazine ) (also known as 3-FPM, 3-FPH and PAL-593) is a phenylmorpholine-based stimulant and fluorinated analogue of phenmetrazine that has been sold online as a designer drug.
3-FPM is a derivative of phenmetrazine. As described by McLaughlin and colleagues
(7), the fluorinated analogs of phenmetrazine contain two chiral centers which yield the potential for four
stereoisomers and two racemic mixtures (i.e., cis- and trans-racemates) (See Fig. 1 in McLaughlin et al).
3-Fluorophenmetrazine is a white, solid, crystalline powder. It was also identified in
yellow, blue or green pellets (tablets).
IUPAC name: 2-(3-fluorophenyl)-3-methylmorpholine; hydrochloride.
Identification and analysis
A number of analytical tests have been used to differentiate 3-FPM from its positional isomers, 2- and 4-FPM,
including gas chromatography-mass spectrometry, liquid chromatography-mass spectrometry, and thin-layer
chromatography (7). All of the methods successfully differentiated 3-FPM from its.
3-FPM is potent at releasing dopamine (DA) and norepinephrine (NE), with half
maximal effective concentration (EC50) values of 43 and 30 nM, respectively, and
less potent at releasing serotonin (5-HT; 2558 nM (1)).