XLR-11 (5″-fluoro-UR-144 or 5F-UR-144) is a drug that acts as a potent agonist for the cannabinoid receptors CB₁ and CB₂ with EC₅₀ values of 98 nM and 83 nM, respectively.

5FUR-144

It is a 3-(tetramethylcyclopropylmethanoyl)indole derivative related to compounds such as UR-144, A-

796,260 and A-834,735, but it is not specifically listed in the patent or scientific literature alongside these other

similar compounds, and appears to have not previously been made by Abbott Laboratories, despite falling within the

claims of patent WO 2006/069196.

Synonyms

5-fluoro UR-144
5-FUR-144

Technical Information

Formal Name

(1-(5-fluoropentyl)-1H-indol-3-yl)(2,2,3,3-tetramethylcyclopropyl)methanone

CAS Number

1364933-54-9

Molecular Formula

C₂₁H₂₈FNO

Formula Weight

329.5

Purity

≥98%

Formulation(Request formulation change)

A neat solid

Solubility

DMF: 30 mg/ml
DMSO: 30 mg/ml
Ethanol: 30 mg/ml
Ethanol:PBS (pH 7.2) (1:4): 0.2 mg/ml

SMILES

FCCCCCN1C=C(C(C2C(C)(C)C2(C)C)=O)C3=C1C=CC=C3

InChi Code

InChI=1S/C21H28FNO/c1-20(2)19(21(20,3)4)18(24)16-14-23(13-9-5-8-12-22)17-11-7-6-10-15(16)17/h6-7,10-11,14,19H,5,8-9,12-13H2,1-4H3

InChi Key

PXLDPUUMIHVLEC-UHFFFAOYSA-N

DEA Schedule

Shipping & Storage Information

Storage

-20°C

Shipping

Room Temperature in continental US; may vary elsewhere

Stability

≥ 3 years

XLR-11 was found to produce rapid, short-lived hypothermic effects in rats at doses of 3 mg/kg and 10 mg/kg, suggesting that it is of comparable potency to APICA and STS-135

BUY 5FUR-144 POWDER XLR-11 (5?-fluoro-UR-144) is a drug that acts as a potent agonist for the cannabinoid receptors CB1 and CB2 with EC50 values of 98 nM and 83 nM, respectively.

It is a 3-(tetramethylcyclopropylmethanoyl)indole derivative related to compounds such as UR-144, A-796,260 and

A-834,735, but it is not specifically listed in the patent or scientific literature alongside these other similar

compounds, and appears to have not previously been made by Abbott Laboratories, despite falling within the claims

of patent WO 2006/069196. XLR-11 was found to produce rapid, short-lived hypothermic effects in rats at doses of 3

mg/kg and 10 mg/kg, suggesting that it is of comparable potency to APICA and STS-135.

Detection
A forensic standard for this compound is available, and a representative mass spectrum has been posted on Forendex.

Side effects
XLR-11 has been linked to hospitalizations due to its use.

Recreational use
XLR-11 was instead first identified by laboratories in 2012 as an ingredient in synthetic cannabis smoking blends, and appears to be a novel compound invented specifically for grey-market recreational use.

Chemical and physical data
Formula: C21H28FNO

Molar mass: 329.459 g·mol?1

See also
FAB-144
JWH-018
STS-135
UR-144
XLR-12