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JWH-019
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Buy JWH-019 Online

$145.00 – $1,550.00

JWH 019 is a cannabimimetic indole that shows a high-affinity for both the central cannabinoid (CB1) and the peripheral cannabinoid (CB2) receptors.

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SKU: N/A Category: Synthetic Cannabinoids Tags: Buy JWH-019 Online, JWH-019 For Sale, Order JWH-019 Online, Where to buy JWH-019 Online
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Description

JWH-019 is an analgesic chemical from the naphthoylindole family that acts as a cannabinoid agonist at both the CB1 and CB2 receptors.

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JWH-019

It is the N-hexyl homolog of the more common synthetic cannabinoid compound JWH-018.

Unlike the butyl homolog JWH-073, which is several times weaker than JWH-018, the hexyl homolog is only slightly less potent, although extending the chain one carbon longer to the heptyl homolog JWH-020 results in dramatic loss of activity.

These results show that the optimum side chain length for CB1 binding in the naphthoylindole series is the five-carbon pentyl chain, shorter than in the classical cannabinoids where a seven-carbon heptyl chain produces the most potent compounds.

This difference is thought to reflect a slightly different binding conformation adopted by the naphthoylindole compounds as compared to the classical cannabinoids, and may be useful in characterizing the active site of the CB1 and CB2 receptors.

JWH-019 Full chemical name: 1-hexyl-3-(naphthalen-1-oyl)indole Other names:1-hexyl-1H-indol-3-yl)-1-naphthalenyl-methanone, JWH-019 CAS number of substance: 209414-08-4 Physical properties: powder Formula: C25H25NO Molar mass of the substance: 355, 471 g/mol Purity of the preparation

Technical Information
Formal Name
(1-hexyl-1H-indol-3-yl)-1-naphthalenyl-methanone
CAS Number
209414-08-4
Molecular Formula
C25H25NO
Formula Weight
355.5
Purity
≥98%
Formulation(Request formulation change)
A crystalline solid
Solubility
  • DMF: 30 mg/ml
  • DMSO: 20 mg/ml
  • Ethanol: 2.5 mg/ml
λmax
218, 247, 315 nm
SMILES
O=C(C1=CC=CC2=C1C=CC=C2)C3=CN(CCCCCC)C4=CC=CC=C43
InChi Code
InChI=1S/C25H25NO/c1-2-3-4-9-17-26-18-23(21-14-7-8-16-24(21)26)25(27)22-15-10-12-19-11-5-6-13-20(19)22/h5-8,10-16,18H,2-4,9,17H2,1H3
InChi Key
PALJPGHWDUHUPO-UHFFFAOYSA-N
JWH-019 6-Hydroxyhexyl metabolite is a major urinary metabolite of JWH-019, a synthetic cannabinoid found in several blends of the herbal mixture Spice or K2. This biomarker is also referred to as the omega hydroxy metabolite of JWH-019 since the hydroxy group is located at the terminal position of the N-hexyl side chain.
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 2 years
JWH-019
(1-Hexyl-1H-indol-3-yl)-1-naphthalenyl-methanone
(1-hexyl-1H-indol-3-yl)(naphthalen-1-yl)methanone
Synthetic cannabinoids
Synthetic cannabinoid receptor agonists
209414-08-4
InChI=1S/C25H25NO/c1-2-3-4-9-17-26-18-23(21-14-7-8-16-24(21)26)25(27)22-15-10-12-19-11-5-6-13-20(19)22/h5-8,10-16,18H,2-4,9,17H2,1H3 
PALJPGHWDUHUPO-UHFFFAOYSA-N 
CCCCCCN1C2=C(C(C(C3=C(C=CC=C4)C4=CC=C3)=O)=C1)C=CC=C2 
C25H25NO
355.4721 g/mol
Additional information
Quantity

10 grams, 100 grams, 25 grams, 250 grams, 50 grams, 500 grams

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