WHAT IS JWH-073 ?
JWH-073, a synthetic cannabinoid, is an analgesic chemical from the

naphthoylindole family that acts as a partial agonist at both the CB1 and CB2 cannabinoid receptors.

It is somewhat selective for the CB1 subtype, with affinity at this subtype

approximately 5x the affinity at CB2.The abbreviation JWH stands for John W. Huffman, one of the inventors of the compound.

JWH 073

On 20 April 2009, JWH-073 was claimed by researchers at the University of

Freiburg to have been found in a “fertiliser” product called “Forest Humus”, along with another synthetic cannabinoid (C8)-CP 47,497.

These claims were confirmed in July 2009 when tests of Spice product, seized
after the legal ban on JWH-018 had gone into effect in Germany, were shown to
contain the unregulated compound JWH-073 instead.

The analgesic effects of cannabinoid ligands, mediated by CB1 receptors are well
established in treatment of neuropathic pain, as well as cancer pain and arthritis.

These compounds work by mimicking the body’s naturally-produced endocannabinoid hormones such as 2-arachidonoylglycerol and anandamide, which are biologically active and can exacerbate or inhibit nerve signaling.

As the cause is poorly understood in chronic pain states, more research and development must be done before we can realize the therapeutic potential of this class of biologic compounds