MDMB-4en-PINACA is a new synthetic indazole cannabinoid. MDMB-4en-PINACA is analogous to 5F-MDMB-
PINACA and has a similar molecular structure. MDMB-4en-PINACA might display high affinity for peripheral CB1
and CB2 cannabinoid receptors. MDMB-4en-PINACA is marketed online as the designer drug cannabinoid.
A chemical researcher, called MDMB-4en-PINACA , is a designer drug with potential physiological and psychoactive effects.
The side-effects of MDMB-4en-PINACA are unknown.
Storage conditions of this chemical: in a cool and dry place. The stability of this chemical compound can last up to 2 years, under the right storage conditions.
Synonyms
- MDMB-PENINACA
- MDMB-PINACA N1-pentyl-4-en isomer
Technical Information
- DMF: 12 mg/ml
- DMSO: 12 mg/ml
- DMSO:PBS (pH 7.2)(1:8): 0.11 mg/ml
- Ethanol: 10 mg/ml
Shipping & Storage Information
The next generation of synthetic cannabinoids: Detection, activity, and potential toxicity of pent-4en and but-3en analogues including MDMB-4en-PINACA
A new class of synthetic cannabinoids has emerged as new psychoactive substances (NPS). Similar in structure to JWH-022, these substances contain alkene modifications to the tail region of the synthetic cannabinoid core
structure, and nomenclature denotes these new analogues as pent-4en or but-3en species. Internationally, two analogues from this new series recently emerged: MDMB-4en-PINACA and MMB-4en-PICA. Previously, data
regarding activity and potential toxicity were not available. In vitro assessment of cannabinoid receptor 1 (CB1)
activation via the β-arrestin 2 recruitment was studied for three (3) pent-4en analogues, one but-3en analogue, and one (1) principal metabolite. MDMB-4en-PINACA (2.47 nM, 239%), MDMB-4en-PICA (11.5 nM, 302%), and
MDMB-3en-BINACA (14.3 nM, 286%) were highly potent and efficacious (comparison: JWH-018
25.3 nM, 100%), while the potencies of MMB-4en-PICA and MDMB-4en-PINACA 3,3-dimethylbutanoic acid were
markedly lower. Modifications to core and tail structural features (i.e., indole vs. indazole) led to relatively small
differences in potency, while changes among the head region led to larger differences. Sample-mining and data-
mining conducted on toxicology samples led to the identification of MDMB-4en-PINACA in 25 forensic toxicology cases, i
