Buy UR-144 Powder (TMCP-018, KM-X1, MN-001, YX-17) is a drug invented by Abbott Laboratories, that acts as a selective full agonist of the peripheral cannabinoid receptor CB2, but with much lower affinity for the psychoactive CB1 receptor.
UR-144
Pharmacology
UR-144 has high affinity for the CB2 receptor with a Ki of 1.8 nM but 83x lower affinity for the CB1 receptor with a Ki
of 150 nM. It was found to possess an EC50 of 421 nM for human CB1 receptors, and 72 nM for human CB2
receptors. UR-144 produces bradycardia and hypothermia in rats at a dose of 10 mg/kg, suggesting weak cannabinoid-like activity.
Good for research.
Chemically it is closely related to other 2,2,3,3-tetramethylcyclopropyl synthetic cannabinoids like A-796,260 and A-
834,735 but with a different substitution on the 1-position of the indole core, in these compounds its 1-pentyl group is replaced with alkylheterocycles like 1-(2-morpholinoethyl) and 1-(tetrahydropyran-4-ylmethyl).
Chemical and physical data
Formula: C21H29NO
Molar mass: 311.461 g/mol g·mol?1
Dose
Inhalation (tentative due to a lack of information)
Range: 2.5 to 20 mg
Most people have been exposed to the drug in the form of blends that contain varying levels of UR-144. Its not wise to use those products.
Timeline
Inhalation (tentative due to a lack of information)
Total: 1 2 hours
Onset: Under 10 minutes
See also
AB-001
AM-1221
4-HTMPIPO
FAB-144
JTE 7-31
JWH-018
N-(S)-Fenchyl-1-(2-morpholinoethyl)-7-methoxyindole-3-carboxamide
XLR-11
Tetramethylcyclopropylfentanyl
Detection
A forensic standard of UR-144 is available, and the compound has been posted on the Forendex website of potential drugs of abuse.
An ELISA immunoassay technique for detecting UR-144 in urine as part of general drug screens has been developed by Tulip Biolabs, Inc.
An Homogeneous Immunoassay that runs on most Clinical Chemistry Analyzers and detects several UR and XLR synthetic cannabinoids has been developed and introduced by Immunalysis Inc. Pomona USA.
